1,3-Dichloroacetone → HCID 22009760, compound

HRID 322278Notes

Reaction equation

[CH:1]1[C:13]2[C:12](=[CH:14][C:15]([NH2:17])=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[Cl:18][CH2:19][C:20]([CH2:22]Cl)=O>>[Cl:18][CH2:19][C:20]1[N:17]=[C:15]([CH:14]=[C:12]2[C:13]3[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=3[C:6]3[C:11]2=[CH:10][CH:9]=[CH:8][CH:7]=3)[O:16][CH:22]=1

Participants

Reactant 2

HCID 107931,3-Dichloroacetone

HCID 2979449-fluorenylideneacetamide

Product 1

HCID 22009760HCID 22009760, compoundYield 36%

Procedure

In substantially the same manner as in Reference Example 47, 9-fluorenylideneacetamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(9-fluorenylidene)methyloxazole. The yield was 36%. Recrystallization from ethyl acetate-hexane gave yellow prisms, mp 175-176° C.

Sources & evidence

ORD record: ord-a3c83f046d934ddb954e5e4a6a2c079f
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211215B1

Reaction notes

Loading…