1,3-Dichloroacetone → HCID 22009778, compound

HRID 322283Notes

Reaction equation

HRID 322283 reaction equation
[C:1]1([C:7]2[O:8][C:9]3[CH:15]=[CH:14][C:13]([C:16]([NH2:18])=[O:17])=[CH:12][C:10]=3[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:19][CH2:20][C:21]([CH2:23]Cl)=O>>[Cl:19][CH2:20][C:21]1[N:18]=[C:16]([C:13]2[CH:14]=[CH:15][C:9]3[O:8][C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)=[N:11][C:10]=3[CH:12]=2)[O:17][CH:23]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 22009589HCID 22009589, compound

Product 1

HCID 22009778HCID 22009778, compoundYield 65%

Procedure

In substantially the same manner as in Reference Example 47, 2-phenyl-5-benzoxazolecarboxamide was allowed to react with 1,3-dichloroacetone to give 5-(4-chloromethyl-2-oxazolyl)-2-phenylbenzoxazole. The yield was 65%. Recrystallization from ethyl acetate-hexane gave brown needles, mp 194-195° C.

Sources & evidence

ORD record
ord-cf2d7897aa964d00a9bb63a6ac35e277
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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