反应详情

In substantially the same manner as in Reference Example 47, 3-methyl-2-thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(3-methyl-2-thienyl)oxazole. The yield was 61%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 95-96° C.