HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dichloroacetone → 4-Chloromethyl-2-(3-methyl-2-thienyl)oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dichloroacetone | HCID 10793 | — |
| Reactant | 3-Methylthiophene-2-carboxamide | HCID 588128 | — |
| Product | 4-Chloromethyl-2-(3-methyl-2-thienyl)oxazole | HCID 22009832 | 61% |
Reaction Steps
In substantially the same manner as in Reference Example 47, 3-methyl-2-thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(3-methyl-2-thienyl)oxazole. The yield was 61%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 95-96° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-6e3384b4939f4fcf97b097459e830109 |
| Source note | uspto-grants-2001_04 |