Sodium Acetate → 2-(2-Thienyl)-4-oxazolylmethanol

HRID 322300Notes

Reaction equation

HRID 322300 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)[O:6][CH:7]=1.C([O-])(=[O:15])C.[Na+]>>[S:9]1[CH:10]=[CH:11][CH:12]=[C:8]1[C:5]1[O:6][CH:7]=[C:3]([CH2:2][OH:15])[N:4]=1

Participants

3

Reactant 2

HCID 517045Sodium AcetateHCID 25295314-(Chloromethyl)-2-(thiophen-2-yl)-1,3-oxazole

Product 1

HCID 220097752-(2-Thienyl)-4-oxazolylmethanolYield 80%

Procedure

In substantially the same manner as in Reference Example 77, 4-chloromethyl-2-(2-thienyl)oxazole was allowed to react with sodium acetate, and then hydrolyzed to give 2-(2-thienyl)oxazolylmethanol. The yield was 80%. Recrystallization from ethyl acetate-hexane gave pale yellow prisms, mp 98-99° C.

Sources & evidence

ORD record
ord-9670a99650744b20a445864b075583b1
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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