Imidazole → 1-[3-(3-Benzyloxyphenyl)propyl]imidazole

HRID 322311Notes

Reaction equation

HRID 322311 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:10]=1)(=O)=O.[NH:23]1[CH:27]=[CH:26][N:25]=[CH:24]1>>[CH2:16]([O:15][C:11]1[CH:10]=[C:9]([CH2:8][CH2:7][CH2:6][N:23]2[CH:27]=[CH:26][N:25]=[CH:24]2)[CH:14]=[CH:13][CH:12]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 227333633-(3-Benzyloxyphenyl)propyl methanesulfonate

Product 1

HCID 220097131-[3-(3-Benzyloxyphenyl)propyl]imidazoleYield 44%

Procedure

In substantially the same manner as in Reference Example 88, 3-(3-benzyloxyphenyl)propyl methanesulfonate was allowed to react with imidazole to give 1-[3-(3-benzyloxyphenyl)propyl]imidazole. The yield was 44%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 82-83° C.

Sources & evidence

ORD record
ord-1002c7a0a09a4c3593c1499cc7232107
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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