HCID 2728534, compound → HCID 22009757, compound

HRID 322321Notes

Reaction equation

HRID 322321 reaction equation
[N:1]1([C:6]2[S:7][CH:8]=[C:9]([C:11](OCC)=[O:12])[N:10]=2)[CH:5]=[CH:4][CH:3]=[CH:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[N:1]1([C:6]2[S:7][CH:8]=[C:9]([CH2:11][OH:12])[N:10]=2)[CH:2]=[CH:3][CH:4]=[CH:5]1

Participants

3

Reactant 2

HCID 2728534HCID 2728534, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 22009757HCID 22009757, compoundYield 69%

Procedure

In substantially the same manner as in Reference Example 77, ethyl 2-(1-pyrrolyl)-4-thiazolecarboxylate was reduced by lithium aluminum hydride to give 2-(1-pyrrolyl)-4-thiazolylmethanol. The yield was 69%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 111-113° C.

Sources & evidence

ORD record
ord-902439555ada4fe4b2b7f9b664e7ed61
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

Loading…