Ethyl 2-(pyridin-3-YL)thiazole-4-carboxylate → (2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol

HRID 322322노트

반응식

HRID 322322 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[S:8][CH:9]=[C:10]([C:12](OCC)=[O:13])[N:11]=2)[CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=2)[CH:2]=1

참가 물질

3

반응물 2

HCID 2824169Ethyl 2-(pyridin-3-YL)thiazole-4-carboxylateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 4961264(2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol수율 16%

실험 절차

In substantially the same manner as in Reference Example 77, ethyl 2-(3-pyridyl)-4-thiazolecarboxylate was reduced by lithium aluminum hydride to give 2-(3-pyridyl)-4-thiazolylmethanol. The yield was 16%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 121-122° C.

출처 및 근거

ORD 기록
ord-851100b51d61425cb5c92627a86a3cdb
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211215B1

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