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Ethyl 2-(pyridin-3-YL)thiazole-4-carboxylate → (2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 2-(pyridin-3-YL)thiazole-4-carboxylate | HCID 2824169 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 生成物 | (2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol | HCID 4961264 | 16% |
反応手順
In substantially the same manner as in Reference Example 77, ethyl 2-(3-pyridyl)-4-thiazolecarboxylate was reduced by lithium aluminum hydride to give 2-(3-pyridyl)-4-thiazolylmethanol. The yield was 16%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 121-122° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211215B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-851100b51d61425cb5c92627a86a3cdb |
| 出典メモ | uspto-grants-2001_04 |