Sodium borohydride → HCID 22009685, compound

HRID 322328Notes

Reaction equation

HRID 322328 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:10][C:9]([C:11](OCC)=[O:12])=[N:8][CH:7]=1.[BH4-].[Na+]>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:10][C:9]([CH2:11][OH:12])=[N:8][CH:7]=1

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 22009825HCID 22009825, compound

Product 1

HCID 22009685HCID 22009685, compoundYield 74%

Procedure

In substantially the same manner as in Reference Example 111, ethyl 5-(2-thienyl)-2-thiazolecarboxylate was subjected to reduction with sodium borohydride to obtain 5-(2-thienyl)-2-thiazolylmethanol. The yield was 74%. Recrystallization from ethyl acetate-hexane gave pale yellow prisms, mp 67-68° C.

Sources & evidence

ORD record
ord-167d7164fea04a78a644b5f25dccaafe
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

Loading…