Thionyl Chloride → HCID 22009767, compound

HRID 322333Notes

Reaction equation

HRID 322333 reaction equation
[C:1]1([C:7]2[CH:16]=[C:15]3[C:10]([CH:11]=[C:12]([CH2:17]O)[CH:13]=[N:14]3)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:21])=O>>[Cl:21][CH2:17][C:12]1[CH:13]=[N:14][C:15]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH:16]=2

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 22009730HCID 22009730, compound

Product 1

HCID 22009767HCID 22009767, compoundYield 96%

Procedure

In substantially the same manner as in Reference Example 73, 7-phenyl-3-quinolylmethanol was reacted with thionyl chloride to obtain 3-chloromethyl-7-phenylquinoline. The yield was 96%. Recrystallization from ethyl acetate-hexane gave colorless prisms, 105-106° C.

Sources & evidence

ORD record
ord-098f26b6880d466f9efbd16490ac8996
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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