Thionyl Chloride → HCID 22009689, compound

HRID 322334Notes

Reaction equation

HRID 322334 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:15]=[C:14]2[C:9]([CH:10]=[C:11]([CH2:16]O)[CH:12]=[N:13]2)=[CH:8][CH:7]=1.S(Cl)([Cl:20])=O>>[Cl:20][CH2:16][C:11]1[CH:12]=[N:13][C:14]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[C:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[CH:15]=2

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 22009839HCID 22009839, compound

Product 1

HCID 22009689HCID 22009689, compoundYield 77%

Procedure

In substantially the same manner as in Reference Example 73, 7-(2-thienyl)-3-quinolylmethanol was reacted with thionyl chloride to obtain 3-chloromethyl-7-(2-thienyl)quinoline. The yield was 77%. Recrystallization from ethyl acetate-hexane gave colorless leaflets, 120-121° C.

Sources & evidence

ORD record
ord-8f32e36694cd49cfa18f2108268e035e
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

Loading…