HCID 4065946, compound → 3-[4-(Benzyloxy)-3-methoxyphenyl]propan-1-ol

HRID 322335Notes

Reaction equation

HRID 322335 reaction equation
[CH2:1]([O:8][C:9]1[CH:21]=[CH:20][C:12]([CH:13]=[CH:14][C:15](OCC)=[O:16])=[CH:11][C:10]=1[O:22][CH3:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH2:1]([O:8][C:9]1[CH:21]=[CH:20][C:12]([CH2:13][CH2:14][CH2:15][OH:16])=[CH:11][C:10]=1[O:22][CH3:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 4065946HCID 4065946, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 145208533-[4-(Benzyloxy)-3-methoxyphenyl]propan-1-olYield 56%

Procedure

In substantially the same manner as in Reference Example 82, ethyl 4-benzyloxy-3-methoxycinnamate was subjected to reduction with lithium aluminum hydride to obtain 3-(4-benzyloxy-3-methoxyphenyl)propanol. The yield was 56%. Recrystallization from ethyl acetate-hexane gave colorless prisms, 57-58° C.

Sources & evidence

ORD record
ord-63bf6bfc321c44ce81df430c711d3926
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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