2-Methylimidazole → HCID 22009727, compound

HRID 322350Notes

Reaction equation

HRID 322350 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.CS(O[CH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]2[N:24]=[C:25](/[CH:28]=[CH:29]/[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[O:26][CH:27]=2)=[CH:17][CH:16]=1)(=O)=O>>[CH3:1][C:2]1[N:3]([CH2:12][CH2:13][CH2:14][C:15]2[CH:16]=[CH:17][C:18]([O:21][CH2:22][C:23]3[N:24]=[C:25](/[CH:28]=[CH:29]/[C:30]4[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=4)[O:26][CH:27]=3)=[CH:19][CH:20]=2)[CH:4]=[CH:5][N:6]=1

Participants

3

Reactant 2

HCID 127492-MethylimidazoleHCID 155216743-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate

Product 1

HCID 22009727HCID 22009727, compoundYield 47%

Procedure

In substantially the same manner as in Working Example 8, 2-methylimidazole was allowed to react with 3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate to give 4-[4-[3-(2-methyl-1-imidazolyl)propyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole. The yield was 47%. Recrystallization form ethyl acetate-hexane gave colorless prisms, mp 93-94° C.

Sources & evidence

ORD record
ord-81bb72ddf0d34b309a90ad07cb12d2de
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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