HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylimidazole → 4-[4-[3-(2-methyl-1-imidazolyl)propyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylimidazole | HCID 12749 | — |
| Reactant | 3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate | HCID 15521674 | — |
| Product | 4-[4-[3-(2-methyl-1-imidazolyl)propyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole | HCID 22009727 | 47% |
Reaction Steps
In substantially the same manner as in Working Example 8, 2-methylimidazole was allowed to react with 3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate to give 4-[4-[3-(2-methyl-1-imidazolyl)propyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole. The yield was 47%. Recrystallization form ethyl acetate-hexane gave colorless prisms, mp 93-94° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-81bb72ddf0d34b309a90ad07cb12d2de |
| Source note | uspto-grants-2001_04 |