2-Phenylimidazole → HCID 69557324, compound

HRID 322358Notes

Reaction equation

HRID 322358 reaction equation
[C:1]1([C:7]2[NH:8][CH:9]=[CH:10][N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CS(O[CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29]2[N:30]=[C:31](/[CH:34]=[CH:35]/[C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[O:32][CH:33]=2)=[CH:23][CH:22]=1)(=O)=O>>[C:36]1(/[CH:35]=[CH:34]/[C:31]2[O:32][CH:33]=[C:29]([CH2:28][O:27][C:24]3[CH:23]=[CH:22][C:21]([CH2:20][CH2:19][CH2:18][CH2:17][N:11]4[CH:10]=[CH:9][N:8]=[C:7]4[C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)=[CH:26][CH:25]=3)[N:30]=2)[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1

Participants

3

Reactant 2

HCID 695912-PhenylimidazoleHCID 155216764-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]butyl methanesulfonate

Product 1

HCID 69557324HCID 69557324, compoundYield 40%

Procedure

In substantially the same manner as in Working Example 8, 2-phenylimidazole was allowed to react with 4-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]butyl methanesulfonate to give 2-[(E)-2-phenylethenyl]-4-[4-[4-(2-phenyl-1-imidazolyl) butyl]phenoxymethyl]oxazole. The yield was 40%. Recrystallization from ethyl acetate-isopropyl ether gave colorless prisms, mp 85-86° C.

Sources & evidence

ORD record
ord-2b3aedb965ba4f6a9011ccc8c4e7a734
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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