1-[3-(4-Hydroxyphenyl)propyl]imidazole → HCID 22009626, compound

HRID 322391Notes

Reaction equation

HRID 322391 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.[S:16]1[C:20]([C:21]2[O:22][CH:23]=[C:24]([CH2:26]Cl)[N:25]=2)=[CH:19][C:18]2[CH:28]=[CH:29][CH:30]=[CH:31][C:17]1=2>>[S:16]1[C:20]([C:21]2[O:22][CH:23]=[C:24]([CH2:26][O:1][C:2]3[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]4[CH:15]=[CH:14][N:13]=[CH:12]4)=[CH:4][CH:3]=3)[N:25]=2)=[CH:19][C:18]2[CH:28]=[CH:29][CH:30]=[CH:31][C:17]1=2

Participants

3

Reactant 2

HCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazoleHCID 22009858HCID 22009858, compound

Product 1

HCID 22009626HCID 22009626, compoundYield 68%

Procedure

In substantially the same manner as in Working Example 48, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 2-(2-benzo[b]thienyl)-4-chloromethyloxazole to give 2-(2-benzo[b]thienyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 68%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 149-150° C.

Sources & evidence

ORD record
ord-03997a533e7f4fd4abdcdd6f11e5883c
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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