1-[4-(4-Hydroxyphenyl)butyl]imidazole → HCID 22009836, compound

HRID 322417Notes

Reaction equation

HRID 322417 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:4][CH:3]=1.Cl[CH2:18][C:19]1[N:20]=[C:21]([C:24]2[S:25][CH:26]=[CH:27][C:28]=2[CH3:29])[O:22][CH:23]=1>>[N:12]1([CH2:11][CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:18][C:19]3[N:20]=[C:21]([C:24]4[S:25][CH:26]=[CH:27][C:28]=4[CH3:29])[O:22][CH:23]=3)=[CH:3][CH:4]=2)[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 220096641-[4-(4-Hydroxyphenyl)butyl]imidazoleHCID 220098324-Chloromethyl-2-(3-methyl-2-thienyl)oxazole

Product 1

HCID 22009836HCID 22009836, compoundYield 87%

Procedure

In substantially the same manner as in Working Example 72, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 4-chloromethyl-2-(3-methyl-2-thienyl)oxazole to give 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(3-methyl-2-thienyl)oxazole. The yield was 87%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 88-89° C.

Sources & evidence

ORD record
ord-e1eaf52b0e264eadb26e5e3450bd0815
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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