HCID 22009805, compound → HCID 22009878, compound

HRID 322424Notes

Reaction equation

HRID 322424 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[N:19]=[C:20](/[CH:23]=[CH:24]/[C:25]2[S:26][CH:27]=[CH:28][CH:29]=2)[O:21][CH:22]=1>>[N:11]1([CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:17][C:18]3[N:19]=[C:20](/[CH:23]=[CH:24]/[C:25]4[S:26][CH:27]=[CH:28][CH:29]=4)[O:21][CH:22]=3)=[CH:3][CH:4]=2)[CH:15]=[CH:14][N:13]=[CH:12]1

Participants

3

Reactant 2

HCID 22009805HCID 22009805, compoundHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009878HCID 22009878, compoundYield 92%

Procedure

In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-[(E)-2-(2-thienyl)ethenyl]oxazole to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-[(E)-2-(2-thienyl)ethenyl]oxazole. The yield was 92%. Recrystallization from ethyl acetate-isopropyl ether gave colorless prisms, mp 131-132° C.

Sources & evidence

ORD record
ord-831303fe411e40d99d599d19b5432739
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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