Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322441Generated: October 25, 2026

4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-oxazole → HCID 22009704, compound

https://huagongshe.com/reaction/322441

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-oxazoleHCID 2529531—
Reactant1-[4-(4-Hydroxyphenyl)butyl]imidazoleHCID 22009664—
ProductHCID 22009704HCID 2200970461%

Reaction Steps

In substantially the same manner as in Working Example 109, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 4-chloromethyl-2-(2-thienyl)oxazole to give 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(2-thienyl)oxazole. The yield was 61%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 106-107° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-027f57b62d2341fa869e798ec41492d2
Source noteuspto-grants-2001_04