1-Chloro-4-(chloromethyl)benzene → HCID 22009769, compound

HRID 322448Notes

Reaction equation

HRID 322448 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][CH:10]=[C:11]([CH2:13][O:14][C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][N:24]4[CH:28]=[CH:27][N:26]=[CH:25]4)=[CH:17][CH:16]=3)[N:12]=2)=[CH:4][CH:3]=1.[Cl:29][C:30]1[CH:37]=[CH:36][C:33]([CH2:34]Cl)=[CH:32][CH:31]=1>>[Cl:29][C:30]1[CH:37]=[CH:36][C:33]([CH2:34][O:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[O:9][CH:10]=[C:11]([CH2:13][O:14][C:15]4[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][N:24]5[CH:28]=[CH:27][N:26]=[CH:25]5)=[CH:17][CH:16]=4)[N:12]=3)=[CH:6][CH:7]=2)=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 135819169HCID 135819169, compound

Product 1

HCID 22009769HCID 22009769, compoundYield 30%

Procedure

In substantially the same manner as in Working Example 131, 2-(4-hydroxyphenyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole was allowed to react with 4-chlorobenzylchloride to give 2-[4-(4-chlorobenzyloxy)phenyl]-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 30%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 151-152° C.

Sources & evidence

ORD record
ord-cadd765ec2704a94998305fd44845dd5
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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