1,3-Benzodioxole, 5-(chloromethyl)- → HCID 22009732, compound

HRID 322449Notes

Reaction equation

HRID 322449 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][CH:10]=[C:11]([CH2:13][O:14][C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][N:24]4[CH:28]=[CH:27][N:26]=[CH:25]4)=[CH:17][CH:16]=3)[N:12]=2)=[CH:4][CH:3]=1.[CH2:29](Cl)[C:30]1[CH:38]=[CH:37][C:36]2[O:35][CH2:34][O:33][C:32]=2[CH:31]=1>>[N:24]1([CH2:23][CH2:22][CH2:21][C:18]2[CH:19]=[CH:20][C:15]([O:14][CH2:13][C:11]3[N:12]=[C:8]([C:5]4[CH:4]=[CH:3][C:2]([O:1][CH2:29][C:30]5[CH:38]=[CH:37][C:36]6[O:35][CH2:34][O:33][C:32]=6[CH:31]=5)=[CH:7][CH:6]=4)[O:9][CH:10]=3)=[CH:16][CH:17]=2)[CH:28]=[CH:27][N:26]=[CH:25]1

Participants

3

Reactant 2

HCID 887131,3-Benzodioxole, 5-(chloromethyl)-HCID 135819169HCID 135819169, compound

Product 1

HCID 22009732HCID 22009732, compoundYield 43%

Procedure

In substantially the same manner as in Working Example 131, 2-(4-hydroxyphenyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole was allowed to react with piperonylchloride to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-[4-(3,4-methylenedioxyphenylmethoxy)phenyl]oxazole. The yield was 43%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 124-125° C.

Sources & evidence

ORD record
ord-6dec2b0016204377a2050e97864b4758
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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