(2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol → HCID 22009701, compound

HRID 322460Notes

Reaction equation

HRID 322460 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=2)[CH:2]=1.O[C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][N:24]2[CH:28]=[CH:27][N:26]=[CH:25]2)=[CH:17][CH:16]=1>>[N:24]1([CH2:23][CH2:22][CH2:21][C:18]2[CH:19]=[CH:20][C:15]([O:13][CH2:12][C:10]3[N:11]=[C:7]([C:3]4[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=4)[S:8][CH:9]=3)=[CH:16][CH:17]=2)[CH:28]=[CH:27][N:26]=[CH:25]1

Participants

3

Reactant 2

HCID 4961264(2-Pyridin-3-yl-1,3-thiazol-4-yl)methanolHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009701HCID 22009701, compoundYield 35%

Procedure

In substantially the same manner as in Working Example 146, 2-(3-pyridyl)-4-thiazolylmethanol was mesylated, which was allowed to react with 1-[3-(4-hydroxyphenyl)propyl]imidazole to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(3-pyridyl)thiazole. The yield was 35%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 67-68° C.

Sources & evidence

ORD record
ord-e854996f929c42859b668ebcb6ec12ff
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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