反应详情

In substantially the same manner as in Working Example 146, 2-(3-pyridyl)-4-thiazolylmethanol was mesylated, which was allowed to react with 1-[3-(4-hydroxyphenyl)propyl]imidazole to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(3-pyridyl)thiazole. The yield was 35%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 67-68° C.