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(2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol → HCID 22009701、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol | HCID 4961264 | — |
| 反応物 | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| 生成物 | HCID 22009701 | HCID 22009701 | 35% |
反応手順
In substantially the same manner as in Working Example 146, 2-(3-pyridyl)-4-thiazolylmethanol was mesylated, which was allowed to react with 1-[3-(4-hydroxyphenyl)propyl]imidazole to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(3-pyridyl)thiazole. The yield was 35%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 67-68° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211215B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-e854996f929c42859b668ebcb6ec12ff |
| 出典メモ | uspto-grants-2001_04 |