4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-thiazole → 4-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-(2-thienyl)thiazole
反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:4][CH:3]=1.Cl[CH2:18][C:19]1[N:20]=[C:21]([C:24]2[S:25][CH:26]=[CH:27][CH:28]=2)[S:22][CH:23]=1>>[N:12]1([CH2:11][CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:18][C:19]3[N:20]=[C:21]([C:24]4[S:25][CH:26]=[CH:27][CH:28]=4)[S:22][CH:23]=3)=[CH:3][CH:4]=2)[CH:16]=[CH:15][N:14]=[CH:13]1参加物
3
実験手順
In substantially the same manner as in Working Example 72, 1-[4-(4-hydroxyphenyl)butyl]imidazole was reacted with 4-chloromethyl-2-(2-thienyl)thiazole to obtain 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(2-thienyl)thiazole. The yield was 82%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 108-109° C.
出典と根拠
- ORDレコード
- ord-c81f3565bdea45759f19e1c48414198b
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06211215B1
反応ノート
読み込み中…