HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-thiazole → 4-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-(2-thienyl)thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-thiazole | HCID 736496 | — |
| Reactant | 1-[4-(4-Hydroxyphenyl)butyl]imidazole | HCID 22009664 | — |
| Product | 4-[4-[4-(1-Imidazolyl)butyl]phenoxymethyl]-2-(2-thienyl)thiazole | HCID 22009754 | 82% |
Reaction Steps
In substantially the same manner as in Working Example 72, 1-[4-(4-hydroxyphenyl)butyl]imidazole was reacted with 4-chloromethyl-2-(2-thienyl)thiazole to obtain 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(2-thienyl)thiazole. The yield was 82%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 108-109° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-c81f3565bdea45759f19e1c48414198b |
| Source note | uspto-grants-2001_04 |