HCID 22009685, compound → HCID 22009745, compound

HRID 322469Notes

Reaction equation

HRID 322469 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:10][C:9]([CH2:11][OH:12])=[N:8][CH:7]=1.O[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][CH2:22][N:23]2[CH:27]=[CH:26][N:25]=[CH:24]2)=[CH:16][CH:15]=1>>[N:23]1([CH2:22][CH2:21][CH2:20][C:17]2[CH:18]=[CH:19][C:14]([O:12][CH2:11][C:9]3[S:10][C:6]([C:2]4[S:1][CH:5]=[CH:4][CH:3]=4)=[CH:7][N:8]=3)=[CH:15][CH:16]=2)[CH:27]=[CH:26][N:25]=[CH:24]1

Participants

3

Reactant 2

HCID 22009685HCID 22009685, compoundHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009745HCID 22009745, compoundYield 66%

Procedure

In substantially the same manner as in Working Example 146, 5-(2-thienyl)-2-thiazolylmethanol was mesylated and then reacted with 1-[3-(4-hydroxyphenyl)propyl]imidazole to obtain 2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-5-(2-thienyl)thiazole. The yield was 66%. Recrystallization from ethyl acetate-hexane gave orange prisms, mp 82-84° C.

Sources & evidence

ORD record
ord-a901603a62fd48c884cb7580408dd4ee
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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