1-[4-(4-Hydroxyphenyl)butyl]imidazole → HCID 22009724, compound

HRID 322472Notes

Reaction equation

HRID 322472 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:4][CH:3]=1.Cl[CH2:18][C:19]1[N:20]=[C:21]([C:24]2[S:25][C:26]([CH3:29])=[CH:27][CH:28]=2)[S:22][CH:23]=1>>[N:12]1([CH2:11][CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:18][C:19]3[N:20]=[C:21]([C:24]4[S:25][C:26]([CH3:29])=[CH:27][CH:28]=4)[S:22][CH:23]=3)=[CH:3][CH:4]=2)[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 220096641-[4-(4-Hydroxyphenyl)butyl]imidazoleHCID 22009850HCID 22009850, compound

Product 1

HCID 22009724HCID 22009724, compoundYield 74%

Procedure

In substantially the same manner as in Working Example 72, 1-[4-(4-hydroxyphenyl)butyl]imidazole was reacted with 4-chloromethyl-2-(5-methyl-2-thienyl)thiazole to obtain 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(5-methyl-2-thienyl)thiazole. The yield was 74%. Recrystallization from ethyl acetate-hexane gave pale yellow needles, mp 81-82° C.

Sources & evidence

ORD record
ord-f556424e7bf44ff98344aa7b4f1f3e27
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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