2-(Chloromethyl)-5-(2-thienyl)oxazole → HCID 22009657, compound

HRID 322473Notes

Reaction equation

HRID 322473 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[O:19][C:20]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)=[CH:21][N:22]=1>>[N:11]1([CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:17][C:18]3[O:19][C:20]([C:23]4[S:24][CH:25]=[CH:26][CH:27]=4)=[CH:21][N:22]=3)=[CH:3][CH:4]=2)[CH:15]=[CH:14][N:13]=[CH:12]1

Participants

3

Reactant 2

HCID 220097052-(Chloromethyl)-5-(2-thienyl)oxazoleHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

Product 1

HCID 22009657HCID 22009657, compoundYield 90%

Procedure

In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was reacted with 2-chloromethyl-5-(2-thienyl)oxazole to obtain 2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-5-(2-thienyl)oxazole. The yield was 90%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 75-76° C.

Sources & evidence

ORD record
ord-853d756973b74d238e14069e0b9664e2
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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