Hydrochloric Acid → (2-Oxo-3-(2-(5,6,7,8-tetrahydro[1,8]-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)acetic acid hydrochloride

HRID 322502Notes

Reaction equation

HRID 322502 reaction equation
[O:1]=[C:2]1[CH:6]([CH2:7][CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[CH2:15][CH2:14][CH2:13][NH:12][C:11]=3[N:10]=2)[CH2:5][CH2:4][N:3]1[CH2:19][C:20]([O:22]CC)=[O:21].[ClH:25]>>[ClH:25].[O:1]=[C:2]1[CH:6]([CH2:7][CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[CH2:15][CH2:14][CH2:13][NH:12][C:11]=3[N:10]=2)[CH2:5][CH2:4][N:3]1[CH2:19][C:20]([OH:22])=[O:21]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 54307208Ethyl (2-Oxo-3-(2-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)acetate

Product 1

HCID 70226426(2-Oxo-3-(2-(5,6,7,8-tetrahydro[1,8]-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)acetic acid hydrochloride

Conditions

Temperature
50 °C

Procedure

A stirred mixture of 2-7 (0.45 g, 1.4 mmol) and 6N HCl (10 mL) was heated at 50° C. for 1 h, followed by concentration to give 2-8 as a yellow oil.

Workup

  1. concentrationfollowed by concentration

Sources & evidence

ORD record
ord-2834f703ab6c4d96aaba33d2a4674685
Source dataset
uspto-grants-2001_04
Patent number
US06211184B1

Reaction notes

Loading…