HCID 10419270, Verbindung → 3-(2-{6-Cyclopropyl-2-oxo-3-[(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-ylmethyl)-amino]-2H-pyridin-1-yl}-acetylamino)-3(S)-(ethynyl)-propionic acid ethyl ester

HRID 322542Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 322542
[CH:1]1([C:4]2[N:9]([CH2:10][C:11](O)=[O:12])[C:8](=[O:14])[C:7]([NH:15][CH2:16][C:17]3[CH:26]=[CH:25][C:24]4[CH2:23][CH2:22][CH2:21][NH:20][C:19]=4[N:18]=3)=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.[CH2:27]([O:29][C:30](=[O:36])[CH2:31][C@H:32]([NH2:35])[C:33]#[CH:34])[CH3:28]>>[CH2:27]([O:29][C:30](=[O:36])[CH2:31][C@H:32]([NH:35][C:11](=[O:12])[CH2:10][N:9]1[C:4]([CH:1]2[CH2:3][CH2:2]2)=[CH:5][CH:6]=[C:7]([NH:15][CH2:16][C:17]2[CH:26]=[CH:25][C:24]3[CH2:23][CH2:22][CH2:21][NH:20][C:19]=3[N:18]=2)[C:8]1=[O:14])[C:33]#[CH:34])[CH3:28]

Komponenten

3

Edukt 2

HCID 10419270HCID 10419270, VerbindungHCID 22008804{6-Cyclopropyl-2-oxo-3-[(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-ylmethyl)-amino]-2H-pyridin-1-yl}-acetic acid

Produkt 1

HCID 538187783-(2-{6-Cyclopropyl-2-oxo-3-[(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-ylmethyl)-amino]-2H-pyridin-1-yl}-acetylamino)-3(S)-(ethynyl)-propionic acid ethyl ester

Versuchsvorschrift

Following the procedures described for Scheme 16, the acid 17-7 was coupled with 3-amino-3(S)-(ethynyl)-propionic acid ethyl ester 2-9 (Zablokie et al, J. Med. Chem., 1995, 38, 2378) to afford the title compound 17-12.

Quellen und Nachweise

ORD-Eintrag
ord-176136cbc0344a59a60f6dd91baef88d
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211184B1

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