HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 10419270, compound → 3-(2-{6-Cyclopropyl-2-oxo-3-[(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-ylmethyl)-amino]-2H-pyridin-1-yl}-acetylamino)-3(S)-(ethynyl)-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 10419270 | HCID 10419270 | — |
| Reactant | {6-Cyclopropyl-2-oxo-3-[(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-ylmethyl)-amino]-2H-pyridin-1-yl}-acetic acid | HCID 22008804 | — |
| Product | 3-(2-{6-Cyclopropyl-2-oxo-3-[(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-ylmethyl)-amino]-2H-pyridin-1-yl}-acetylamino)-3(S)-(ethynyl)-propionic acid ethyl ester | HCID 53818778 | — |
Reaction Steps
Following the procedures described for Scheme 16, the acid 17-7 was coupled with 3-amino-3(S)-(ethynyl)-propionic acid ethyl ester 2-9 (Zablokie et al, J. Med. Chem., 1995, 38, 2378) to afford the title compound 17-12.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211184B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-176136cbc0344a59a60f6dd91baef88d |
| Source note | uspto-grants-2001_04 |