反应详情

A solution of the pyrazinone 18-3 (5 g, 15.3 mmol) and 4 methoxybenzylamine (6.0 mL, 45.9 mmol) in EtOAc (60 mL) was heated at 80° C. for 2 h. The solution was cooled and filtered. The filtrate was concentrated in vacuo, the residue swished with MeOH and filtered to afford the title compound as a solid:

1. temperatureThe solution was cooled
2. filtrationfiltered
3. concentrationThe filtrate was concentrated in vacuo
4. filtrationfiltered