反应详情

A solution of 114 (1.9 g) in DMF (100 mL) was treated with SnCl2H2O (4 g). After 4 h, additional SnCl2—2H2O (1 g) was added three times over three days. The solvent was then evaporated, the residue suspended in H2O-EtOAc, the mixture neutralized with 5N NaOH, and the mixture filtered. The organics were separated, washed with brine, dried, and the solvent evaporated to give a brown foam (1.9 g).

1. customThe solvent was then evaporated
2. filtrationthe mixture filtered
3. customThe organics were separated
4. washwashed with brine
5. customdried
6. customthe solvent evaporated