o-Tolylacetic acid → 2-[(2-methylphenyl)acetamido]butyric Acid Iso-butyl Ester

HRID 322661Notes

Reaction equation

HRID 322661 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[CH3:1])[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 69519o-Tolylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 545734982-[(2-methylphenyl)acetamido]butyric Acid Iso-butyl Ester

Procedure

Following General Procedure I′ above and using 2-methylphenylacetic acid (Aldrich) and iso-butyl 2-aninobutyrate (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-c3fdd35d5c05495390a3ee3dc95b861d
Source dataset
uspto-grants-2001_04
Patent number
US06211235B1

Reaction notes

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