Dimethylformamide → 2-(3,5-Difluorophenyl)acetyl chloride

HRID 322692Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 322692
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([F:8])[CH:7]=1.CN(C=O)C.C(Cl)(=O)C([Cl:21])=O>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([Cl:21])=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 1454243,5-Difluorophenylacetic acid

Produkt 1

HCID 27827232-(3,5-Difluorophenyl)acetyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

3,5-Difluorophenylacetic acid (30 g, 0.174 mol) (Aldrich) was dissolved in dichloromethane and this solution was cooled to 0° C. DMF (0.5 mL, catalytic) was added followed by the dropwise addition of oxalyl chloride (18 mL, 0.20 mol) over a 5 minute period. The reaction was stirred for 3 h and then rotoevaporated at reduced pressure to a residue which was placed on a high vacuum pump for 1 h to afford 3,5-difluorophenylacetyl chloride as a thin yellow oil. Other acid chlorides can be prepared in a similar manner.

Aufarbeitung

  1. waitwas placed on a high vacuum pump for 1 h

Quellen und Nachweise

ORD-Eintrag
ord-349d0a55ff5c4dd5afd9eec06e5761cd
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211235B1

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