Ethyl formate → HCID 7073861, compound

HRID 322699Notes

Reaction equation

HRID 322699 reaction equation
[CH3:1][C@H:2]([NH2:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH:10](OCC)=[O:11]>>[CH3:1][C@H:2]([NH:9][CH:10]=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 758181-Phenethylamine, (-)-

Product 1

HCID 7073861HCID 7073861, compound

Conditions

Temperature
55 °C

Procedure

(S)-(−)-α-Methylbenzylamine (1 molar eq., Aldrich) was treated with ethyl formate (80 molar eq.; Aldrich). A precipitate formed immediately. The suspension was heated to reflux (55° C.) for 3 hours. The precipitate went into solution upon heating. The solution was cooled to ambient temperature and concentrated via rotary evaporation. The resultant solid was used without purification.

Workup

  1. customA precipitate formed immediately
  2. temperatureThe suspension was heated
  3. temperatureupon heating
  4. temperatureThe solution was cooled to ambient temperature
  5. concentrationconcentrated via rotary evaporation
  6. customThe resultant solid was used without purification

Sources & evidence

ORD record
ord-a8c0ebabe9c44ebdaedf3c44aa9a1437
Source dataset
uspto-grants-2001_04
Patent number
US06211235B1

Reaction notes

Loading…