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HRID 322722作成日：2026年10月25日

(S)-Methyl 2-amino-6-((tert-butoxycarbonyl)amino)hexanoate → N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-Nepsilon-(tert-butoxycarbonyl)-L-lysine Methyl Ester

https://huagongshe.com/reaction/322722

反応式

関与物質

役割名称HCID仕込み量
反応物(S)-Methyl 2-amino-6-((tert-butoxycarbonyl)amino)hexanoateHCID 7018776—
反応物(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 12135350—
生成物N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-Nepsilon-(tert-butoxycarbonyl)-L-lysine Methyl EsterHCID 20642604—

反応手順

Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and Nε-(tert-butoxycarbonyl)-L-lysine methyl ester (Bachem), the title compound was prepared as an oil. The reaction was monitored by tlc (Rf=0.40 in 50% EtOAc/hexanes) and the product was purified by flash chromotography using 50% EtOAc/hexanes as the eluent.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06211235B1
出典データセットuspto-grants-2001_04
ORD IDord-b8ac866f51894f699edcab131f6d81aa
出典メモuspto-grants-2001_04