L-Alanine, ethyl ester, hydrochloride (1:1) → HCID 22895015, compound

HRID 322737Notes

Reaction equation

HRID 322737 reaction equation
ClC1C=C(Cl)C(Cl)=CC=1O[C:11](=[O:27])[C@H:12]([CH3:26])[NH:13][C:14](=[O:25])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=1.Cl.[CH2:29]([O:31][C:32](=[O:36])[C@H:33]([CH3:35])[NH2:34])[CH3:30]>CCOC(C)=O>[CH2:29]([O:31][C:32](=[O:36])[C@H:33]([CH3:35])[NH:34][C:11](=[O:27])[C@H:12]([CH3:26])[NH:13][C:14](=[O:25])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([N+:22]([O-:24])=[O:23])[CH:17]=1)[CH3:30]

Participants

4

Reactant 2

HCID 2724356L-Alanine, ethyl ester, hydrochloride (1:1)HCID 20780358HCID 20780358, compound

Product 1

HCID 22895015HCID 22895015, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Following General Procedure Z and using N-(3-nitrophenylacetyl)-L-alanine 2,4,5-trichlorophenyl ester (from Example D8 above) and L-alanine ethyl ester hydrochloride (Sigma), the title compound was prepared as a solid (mp =193-195° C.). The reaction was monitored by tlc (Rf=0.4 in EtOAc) and the product was purified by silica gel chromatography using EtOAc as the eluent.

Workup

  1. customthe product was purified by silica gel chromatography

Sources & evidence

ORD record
ord-f7afed77d5434a108fe3eb02b8a1fcfa
Source dataset
uspto-grants-2001_04
Patent number
US06211235B1

Reaction notes

Loading…