反应详情

To 1.8 g of the ethyl 1-(3-tert-butoxycarbonylamino-4,6-difluorophenyl)-6,7-difluoro-5,8-dimethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate obtained in the Reference Example 15 was added 10 ml of 12N hydrochloric acid, and the mixture was stirred under heating and reflux condition for 4 hours. After allowing to cool, the solid precipitate was collected by filtration, washed with water and ethanol successively, and dried to obtain 1.2 g of the title compound.

1. temperatureunder heating
2. temperaturereflux condition for 4 hours
3. temperatureto cool
4. filtrationthe solid precipitate was collected by filtration
5. washwashed with water and ethanol successively
6. customdried