反应详情

温度

60 °C

A mixture of methyl (Z)-2-benzoylamino-3-(2,4-dibenzyloxyphenyl)acrylate (1.6 g) and aqueous potassium hydroxide in methanol (35 mL, 15%) is stirred and heated at 60° C. for 6 hours. The reaction mixture is diluted with water (20 mL), acidified to pH 1 by addition of concentrated hydrochloric acid and the resulting solid filtered. Recrystallisation fro ethyl acetate gives (Z)-2-benzoylamino-3-(2,4-dibenzyloxyphenyl)acrylic acid (0.72 g) as a white solid, m.p. 212-213° C. [Elemental analysis:- C,75.2; H,5.28; N,2.83%. Calculated :- C,75.1; H,5.26; N,2.92%].

1. filtrationthe resulting solid filtered
2. customRecrystallisation fro ethyl acetate