反应详情

A mixture of 2,4-dibenzyloxybenzaldehyde (2 g), hydroxylamine hydrochloride (0.45 g) and pyridine (0.53 mL) in ethanol (20 mL) is heated at reflux for 1 hour. The solvent is then removed in vacuo, the residue dissolved in ethyl acetate and the solution washed with 1 N hydrochloric acid then with brine. Removal of the solvent in vacuo gives a beige coloured solid which crystallises from a mixture of ether and petroleum ether to give 2,4-dibenzyloxybenzaldehyde oxime in the form of a white solid, m.p., 130° C. [Elemental analysis:- C,76.1; H,5.75; N,4.28%. Calculated:- C,75.7; H,5.74; N,4.20%].

1. temperatureis heated
2. temperatureat reflux for 1 hour
3. customThe solvent is then removed in vacuo
4. dissolutionthe residue dissolved in ethyl acetate
5. washthe solution washed with 1 N hydrochloric acid
6. customRemoval of the solvent in vacuo
7. customgives a beige coloured solid which
8. customcrystallises from a mixture of ether and petroleum ether