Ammonia → HCID 53886046, compound

HRID 322914Notes

Reaction equation

HRID 322914 reaction equation
C[O:2][C:3]([C:5]1[NH:9][N:8]=[C:7]([C:10]2[CH:29]=[CH:28][C:27]([O:30][CH2:31][C:32]3[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=3)=[CH:26][C:11]=2[O:12][C@@H:13]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:14][CH2:15][C:16]([OH:18])=[O:17])[CH:6]=1)=O.[NH3:38]>CO>[C:3]([C:5]1[NH:9][N:8]=[C:7]([C:10]2[CH:29]=[CH:28][C:27]([O:30][CH2:31][C:32]3[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=3)=[CH:26][C:11]=2[O:12][C@@H:13]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:14][CH2:15][C:16]([OH:18])=[O:17])[CH:6]=1)(=[O:2])[NH2:38]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 54275016HCID 54275016, compound

Product 1

HCID 53886046HCID 53886046, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(R)-4-[2-(5-methoxycarbonylpyrazol-3-yl)-5-(3-pyridylmethoxy)phenoxy]-4-(2-methylphenyl)butanoic acid (0.2 g) is dissolved in methanol (20 mL) and concentrated aqueous ammonia (20 mL). After standing at room temperature overnight .the solution is evaporated to dryness and the residue triturated successively with ether and ethyl acetate to give (R)-4-[2-(5-carbamoylpyrazol-3-yl)-5-(3-pyridylmethoxy)-phenoxy]-4-(2-methylphenyl)butanoic acid (0.035 g) as a white powder, mp 180-192° C.

Workup

  1. custom.the solution is evaporated to dryness
  2. customthe residue triturated successively with ether and ethyl acetate

Sources & evidence

ORD record
ord-7110b42083724137afd22b342222fafb
Source dataset
uspto-grants-2001_04
Patent number
US06211234B1

Reaction notes

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