Ammonia → HCID 53886046, compound

Participants

Reaction Steps

(R)-4-[2-(5-methoxycarbonylpyrazol-3-yl)-5-(3-pyridylmethoxy)phenoxy]-4-(2-methylphenyl)butanoic acid (0.2 g) is dissolved in methanol (20 mL) and concentrated aqueous ammonia (20 mL). After standing at room temperature overnight .the solution is evaporated to dryness and the residue triturated successively with ether and ethyl acetate to give (R)-4-[2-(5-carbamoylpyrazol-3-yl)-5-(3-pyridylmethoxy)-phenoxy]-4-(2-methylphenyl)butanoic acid (0.035 g) as a white powder, mp 180-192° C.

Provenance & Evidence