HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-benzyloxy-2-(1-o-tolylethoxy)benzoate → 4-Benzyloxy-2-(1-o-tolylethoxy)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-benzyloxy-2-(1-o-tolylethoxy)benzoate | HCID 22010393 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | 4-Benzyloxy-2-(1-o-tolylethoxy)benzoic acid | HCID 22010490 | — |
Reaction Steps
A solution of methyl 4-benzyloxy-2-(1-o-tolylethoxy)benzoate (2.8 g) in 15% KOH in MeOH (50 mL) is refluxed for 3 hours. The solution is evaporated, the residue treated with water, brought to pH 1 with concentrated HCl, extracted with dichloromethane. The extract is dried and evaporated to give 4-benzyloxy-2-(1-o-tolylethoxy)benzoic acid as a colourless solid, m.p. 110-113° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211234B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-31ad970e89394ac99e0786053914632d |
| Source note | uspto-grants-2001_04 |