Hydrazine hydrate (1:1) → HCID 10502648, compound

HRID 322927Notes

Reaction equation

HRID 322927 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[C:23](=O)[CH2:24][C:25](=O)[C:26]([O:28][CH2:29][CH3:30])=[O:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:34][NH2:35]>C(O)C>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[C:23]1[CH:24]=[C:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])[NH:35][N:34]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 11796971Ethyl 4-(2,4-dibenzyloxyphenyl)-2,4-dioxobutanoate

Product 1

HCID 10502648HCID 10502648, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl 4-(2,4-dibenzyloxyphenyl)-2,4-dioxobutanoate (3.23 g) in ethanol (10 mL) is treated with hydrazine hydrate (0.4 mL), refluxed for 2 hours and then cooled to room temperature. The mixture is filtered to yield ethyl 3-(2,4-dibenzyloxyphenyl)-pyrazole-5-carboxylate as a solid (1.5 g).

Workup

  1. temperaturerefluxed for 2 hours
  2. filtrationThe mixture is filtered

Sources & evidence

ORD record
ord-22f5c21106cf4d6aa75d6de132395507
Source dataset
uspto-grants-2001_04
Patent number
US06211234B1

Reaction notes

Loading…