HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Hydroxyacetophenone → 1-[4-(Benzyloxy)phenyl]ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Hydroxyacetophenone | HCID 7469 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 1-[4-(Benzyloxy)phenyl]ethan-1-one | HCID 245226 | 90.3% |
Reaction Steps
A mixture of 4-hydroxyacetophenone (30 g), potassium carbonate (33.4 g), potassium iodide (1 g) and benzyl bromide (41.4 g) in methyl ethyl ketone (500 mL) is heated at reflux for 18 hours. The cooled reaction mixture is filtered and the filtrate evaporated. The residue is crystallised from cyclohexane to give 4-benzyloxyacetophenone (45 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211234B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-a73ef722221d471fa9656b8906ca8a09 |
| Source note | uspto-grants-2001_04 |