反应详情

5-hydroxy-2-methylbenzaldehyde (3.4 g) is added portionwise to a stirred suspension of sodium hydride (1.2 g, 60% dispersion in mineral oil). The reaction mixture is stirred at room temperature for 45 minutes, 2-(trimethylsilyl)ethoxymethyl chloride (5 g) is added slowly and stirring continued for a further 3 hours. The mixture is evaporated and the residue partitioned between ethyl acetate (50 mL) and water (150 mL). The organic phase is washed with brine (150 mL) dried over magnesium sulphate and evaporated to give 2-methyl-5-(2-(trimethylsilyl)ethoxymethoxy)benzaldehyde (6.87 g) as a red-brown oil.

1. stirringstirring
2. waitcontinued for a further 3 hours
3. customThe mixture is evaporated
4. customthe residue partitioned between ethyl acetate (50 mL) and water (150 mL)
5. washThe organic phase is washed with brine (150 mL)
6. dry with materialdried over magnesium sulphate
7. customevaporated