Ethyl Acetate → HCID 5697817, compound

HRID 323129Notes

Reaction equation

HRID 323129 reaction equation
[N+](C1C=CC(C([O:12][C:13]2[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=2[NH:20][C:21](=[O:31])[C:22]2[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=2)=O)=CC=1)([O-])=O.[OH-].[Na+].C(OCC)(=O)C>O>[OH:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[NH:20][C:21](=[O:31])[C:22]1[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 12439867HCID 12439867, compound

Product 1

HCID 5697817HCID 5697817, compoundYield 48.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of N-[2-(4-nitrophenylcarbonyloxy)-4-methylphenyl]-4-nitrobenzamide (12.5 g) was added 1N sodium hydroxide (20 ml) at ambient temperature. After 3 hours, ethyl acetate (100 ml) and water (200 ml) was added to this solution and resulting solid was filtered and washed with water and diethyl ether to give N-(2-hydroxy-4-methylphenyl)-4-nitrobenzamide (3.9 g) as yellow crystal.

Workup

  1. customresulting solid
  2. filtrationwas filtered
  3. washwashed with water and diethyl ether

Sources & evidence

ORD record
ord-1e157a4d32da4eacad9f74ceed9fe322
Source dataset
uspto-grants-2001_04
Patent number
US06211242B1

Reaction notes

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