反应详情

A solution of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-ethoxycarbonylphenyl)benzamide (500 mg) in a mixture of ethanol (20 ml) and 1N sodium hydroxide (2 ml) was heated at reflux for 4 hours and ethanol was evaporated in vacuo. Water (5 ml) was added to the residue and the aqueous solution was adjusted to pH 2 with 1N hydrochloric acid. The precipitate was filtered to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-carboxyphenyl)benzamide (435 mg) as a white powder.

1. temperaturewas heated
2. temperatureat reflux for 4 hours
3. customethanol was evaporated in vacuo
4. additionWater (5 ml) was added to the residue
5. filtrationThe precipitate was filtered